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15+ Years at Wyss Institute at Harvard University | 10+ Years in Pharmaceutical Development Industry

Colorful Lab Glassware

Explore the peer-reviewed research defining Stafford’s leadership in biomaterials and targeted drug delivery. This body of work forms the scientific foundation of his consultancy, proving his ability to move complex therapies from preclinical discovery to clinical reality. For healthcare stakeholders, these publications validate a strategic, regulatory-ready approach to pharmaceutical innovation that translates high-level technical excellence into improved patient outcomes.

Patents

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Click-crosslinked hydrogels and methods of use

R Desai, NS Joshi, DJ Mooney, ST Koshy, AG Stafford

US Patent 10,821,208

Reduced and oxidized polysaccharides and methods of use thereof

DJ Mooney, A Stafford, R Desai, K Martinick

US Patent 11,771,767

Pathogen vaccines and methods of producing and using the same

M Super, EJ Doherty, MJ Cartwright, D White, A Stafford, A Graveline, ...

US Patent 11,638,748

Click-crosslinked hydrogels and methods of use thereof

DJ Mooney, A Stafford, K Adu-Berchie

WO2025165744A1

Research Publications

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'26

Kinetics of De Novo Bone and Bone Marrow Niche Formation With Hybrid Click Cryogels S Lee, K Adu‐Berchie, AS Sharda, T To, N Dimitrakakis, A Stafford, ... Advanced Healthcare Materials 15 (17), e05821

'25

In Vivo Accumulation of Regulatory T Cells Using Eliglustat‐Loaded Cryogels EB Vitner, G Bovone, WH Jung, J Lou, H Hankenson, MT Dacus, ... Advanced Healthcare Materials 14 (22), 2501529

'24

First-in-Human Clinical Trial of Vaccination with WDVAX, a Dendritic Cell–Activating Scaffold Incorporating Autologous Tumor Cell Lysate, in Patients with Metastatic Melanoma FS Hodi, A Giobbie-Hurder, K Adu-Berchie, S Ranasinghe, A Lako, ... Cancer Immunology Research 13 (7), 978-989

Perivascular CLICK-gelatin delivery of thrombospondin-2 small interfering RNA decreases development of intimal hyperplasia after arterial injury L Mota, M Zhu, J Li, M Contreras, T Aridi, JN Tomeo, A Stafford, ... FASEB journal: official publication of the Federation of American Societies

'23

Immune‐responsive biodegradable scaffolds for enhancing neutrophil regeneration MD Kerr, DA McBride, WT Johnson, AK Chumber, AJ Najibi, BR Seo, ... Bioengineering & Translational Medicine 8 (1), e10309

'22

Enhancing adoptive T cell therapy with synergistic host immune engagement promotes long-term protection against solid tumors K Adu-Berchie, JM Brockman, Y Liu, DKY Zhang, AJ Najibi, A Stafford, ... bioRxiv, 2022.09. 10.507437

Mechanical checkpoint regulates monocyte differentiation in fibrotic niches KH Vining, AE Marneth, K Adu-Berchie, JM Grolman, CM Tringides, Y Liu, ... Nature Materials 21 (8), 939-950

STING activation promotes robust immune response and NK cell–mediated tumor regression in glioblastoma models G Berger, EH Knelson, JL Jimenez-Macias, MO Nowicki, S Han, ... Proceedings of the National Academy of Sciences 119 (28), e2111003119

'21

Scaffold vaccines for generating robust and tunable antibody responses AJ Najibi, MO Dellacherie, TY Shih, EJ Doherty, DA White, ... Advanced Functional Materials 32 (16), 2110905

Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock M Super, EJ Doherty, MJ Cartwright, BT Seiler, F Langellotto, ... Nature biomedical engineering 6 (1), 8-18

Mechanical checkpoint regulates monocyte differentiation in fibrotic matrix KH Vining, AE Marneth, K Adu-Berchie, CM Tringides, JM Grolman, Y Liu, ... Blood 138, 2539

Delivery of Thrombospondin-2 Small Interfering RNA for Suppression of Intimal Hyperplasia JR Li, K Piper, P Liang, M Zhu, M Contreras, A Stafford, D Mooney, ... JVS-Vascular Science 2, 277

'20

Single‐shot mesoporous silica rods scaffold for induction of humoral responses against small antigens MO Dellacherie, A Li, BY Lu, CS Verbeke, L Gu, AG Stafford, EJ Doherty, ... Advanced Functional Materials 30 (38), 2002448

Modular biomaterials vaccine technology protects against multiple pathogens and septic shock M Super, EJ Doherty, MJ Cartwright, BT Seiler, DA White, F Langellotto, ... bioRxiv, 2020.02. 25.964601

'19

Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels KH Vining, A Stafford, DJ Mooney Biomaterials 188, 187-197

'18

Hydrolytically-degradable click-crosslinked alginate hydrogels A Lueckgen, DS Garske, A Ellinghaus, RM Desai, AG Stafford, ... Biomaterials 181, 189-198

A facile approach to enhance antigen response for personalized cancer vaccination AW Li, MC Sobral, S Badrinath, Y Choi, A Graveline, AG Stafford, ... Nature materials 17 (6), 528-534

Tough composite hydrogels with high loading and local release of biological drugs J Li, E Weber, S Guth‐Gundel, M Schuleit, A Kuttler, C Halleux, N Accart, ... Advanced healthcare materials 7 (9), 1701393

'17

Production and Characterization of Synthetic ErbB2 Virosomes for Vaccination Against Breast Cancer AG Stafford Harvard University

Injectable nanocomposite cryogels for versatile protein drug delivery ST Koshy, DKY Zhang, JM Grolman, AG Stafford, DJ Mooney Acta biomaterialia 65, 36-43

VEGF and IGF delivered from alginate hydrogels promote stable perfusion recovery in ischemic hind limbs of aged mice and young rabbits EM Anderson, EA Silva, Y Hao, KD Martinick, SA Vermillion, AG Stafford, ... Journal of vascular research 54 (5), 288-298

Adapting the innate immune system to develop long-lived vaccines to bacterial pathogens M Super, E Doherty, M Cartwright, A Stafford, O Ali, D White, A Graveline, ... The Journal of Immunology 198 (Supplement_1), 73.7-73.7

'16

Adjuvant‐loaded subcellular vesicles derived from disrupted cancer cells for cancer vaccination AS Cheung, ST Koshy, AG Stafford, MMC Bastings, DJ Mooney Small 12 (17), 2321-2333

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